Publications by authors named "M Erlewyn-Lajeunesse"
Article Synopsis
- * A survey conducted across 56 European countries revealed that while many pediatricians are aware of allergy guidelines, only a small percentage are familiar with specific allergy competencies from the EAACI.
- * Access to allergy investigations and treatment varies among practitioners, with the main barriers to referrals being the belief that conditions can be managed within their facilities, despite many recognizing the need for specialist assessment.
Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study).
J Pediatr Gastroenterol Nutr
March 2024
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.
View Article and Find Full Text PDFArticle Synopsis
- Cow milk (CM) allergy is a common issue in young children, but current diagnostic methods are often unreliable or risky.
- This study aimed to identify specific characteristics of T cells in CM-allergic patients that could serve as a new diagnostic marker.
- The researchers found significant differences in the quantity and behavior of CM-specific T cells in allergic patients, leading to the development of a flow-cytometry assay that could help with diagnosing CM allergy more effectively.
Background: No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown.
Methods: We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving children 1 to 3 years of age with peanut allergy confirmed by a double-blind, placebo-controlled food challenge. Patients who had an eliciting dose (the dose necessary to elicit an allergic reaction) of 300 mg or less of peanut protein were assigned in a 2:1 ratio to receive epicutaneous immunotherapy delivered by means of a peanut patch (intervention group) or to receive placebo administered daily for 12 months.
Article Synopsis
- The study aimed to identify factors predicting delayed gastric emptying (DGE) in children and assess their response to treatment over time.
- It involved analyzing data from 285 children aged 0 to 18, focusing on symptoms, medical history, and outcomes over a 2-year follow-up period.
- Key findings indicated that prior abdominal surgery significantly predicted DGE, and most children experienced a notable improvement in symptoms and reduced medication usage after two years.