Synergistic Anticancer Effects of Bleomycin and Hesperidin Combination on A549 Non-Small Cell Lung Cancer Cells: Antiproliferative, Apoptotic, Anti-Angiogenic, and Autophagic Insights.

: This study investigated the combined effects of hesperidin (Hesp), a natural flavonoid, with bleomycin (BL), a commonly used chemotherapy agent, on A549 human lung cancer cells. : Key parameters assessed included cell viability, colony formation, and cell migration, alongside the expression of apoptotic and autophagic markers (p53, p21, Bax, cleaved PARP, and Beclin-1), VEGF levels, and caspase-3 activity. : The findings revealed that the Hesp + BL combination significantly amplified antiproliferative, apoptotic, anti-angiogenic, and autophagic effects compared to either treatment alone.

Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line.

Cancer remains one of the most formidable diseases globally and continues to be a leading cause of mortality. While chemotherapeutic agents are crucial in cancer treatment, they often come with severe side effects. Furthermore, the development of acquired drug resistance poses a significant challenge in the ongoing battle against cancer.

Novel ferritin L-chain gene variant in a case of hereditary hyperferritinemia-cataract syndrome without family history.

Introduction: Hereditary Hyperferritinemia-Cataract Syndrome (HHCS, MIM #600886) is a rare autosomal dominant genetic disorder characterized by elevated serum ferritin levels and early-onset cataracts. This condition is caused by mutations in the iron-responsive element (IRE) within the 5' untranslated region (UTR) of the ferritin light chain (, *) gene. In this study, we report a case involving elevated ferritin levels and a history of cataracts associated with a novel variant in the gene, in the absence of any familial history of the disease.