A population pharmacokinetic model for sertraline in women during the perinatal period-A contribution from the ConcePTION project.

Aims: Sertraline is frequently prescribed for mental health conditions in both pregnant and breastfeeding women. According to the limited available data, only small amounts of sertraline are transferred into human milk, yet with a large amount of unexplained interindividual variability. This study aimed to develop a population pharmacokinetic (popPK) model to describe the pharmacokinetics of sertraline during the perinatal period and explain interindividual variability.

The Maternal Psychic Impact of Infection by SARS-CoV-2 during Pregnancy: Results from a Preliminary Prospective Study.

Due to a higher risk of maternal complications during pregnancy, as well as pregnancy complications such as stillbirth, SARS-CoV-2 contamination during pregnancy is a putative stress factor that could increase the risk of perinatal maternal mental health issues. We included women older than 18 years, who delivered a living baby at the Geneva University Hospitals' maternity wards after 29 weeks of amenorrhea (w.a.

Perinatal arterial ischemic stroke: how informative is the placenta?

Neuroplacentology is an expanding field of interest that addresses the placental influence on fetal and neonatal brain lesions and on further neurodevelopment. The objective of this study was to clarify the link between placental pathology and perinatal arterial ischemic stroke (PAIS). Prior publications have reported different types of perinatal stroke with diverse methodologies precluding firm conclusions.

The Interplay Between Maternal and Paternal Senses of Efficacy Moderates the Link Between Perinatal Parental Stress and Family Alliance at 3 Months.

Both parents may report high levels of stress during the perinatal period with possible negative consequences for parental well-being and child development. Parental sense of efficacy moderates the effect of stress. To date, no studies have assessed links between parental stress and mother-father-infant interactions in terms of family alliance and the extent to which each parent's sense of efficacy moderates these links.