Evaluation of cooperative antileukemic effects of nilotinib and vildagliptin in Ph chronic myeloid leukemia.

Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although the disease can be kept under control using BCR/ABL1 tyrosine kinase inhibitors (TKIs) in most cases, some patients relapse or have resistant disease, so there is a need to identify new therapeutic targets in this malignancy. Recent data suggest that leukemic SCs (LSCs) in CML display the stem-cell (SC)-mobilizing cell surface enzyme dipeptidyl-peptidase IV (DPPIV = CD26) in an aberrant manner.

NAD(P)H-independent asymmetric C=C bond reduction catalyzed by ene reductases by using artificial co-substrates as the hydrogen donor.

To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C=C bonds, four types of hydrogen donor, encompassing more than 50 candidates, were investigated. Six highly potent, cheap, and commercially available co-substrates were identified that (under the optimized conditions) resulted in conversions and enantioselectivities comparable with, or even superior to, those obtained with traditional two-enzyme nicotinamide adenine dinucleotide phosphate (NAD(P)H)-recycling systems.

One row anastomosis in colonic operations with antibiotic prophylaxis.

Eighty-nine patients who underwent elective operations and 26 patients who underwent nonelective operations for diseases of the large intestine were studied for mortality and morbidity. In the patients who underwent elective operations, there was no anastomotic leakage or wound infection and only 1 per cent mortality. Additionally, 2 per cent nonfatal surgical complications were observed.

[Surgical treatment of acute cholecystitis (authors' transl)].

On the basis of 15 resp. 25 years of experience with surgical treatment of acute cholecystitis the authors evaluate their results of urgent and acute operations in 1.080 patients in whom the intensive conservative treatment of acute attacks did not sufficiently influence the symptoms of acute cholecystitis.