Publications by authors named "M Entezari"
Background: breast cancer-associated fibroblast (CAF) is linked to metastasis and is poor for breast cancer prognosis. Since Clostridium Toxin A (Botox-A) had represented a cytotoxic effect on fibroblasts, this study aims to assess Botox-A cytotoxicity in both normal fibroblasts and exosome-induced CAFs.
Material And Method: the serum exosomes of 40 BC patients and 30 healthy individuals were isolated and lncRNA H19 (lnch19) levels were assessed by qRT-PCR method.
Lung cancer (LC) is one of the most common causes of cancer-related death worldwide. It has been demonstrated that the prognosis of current drug treatments is affected by a variety of factors, including late stage, tumor recurrence, inaccessibility to appropriate treatments, and, most importantly, chemotherapy resistance. Non-coding RNAs (ncRNAs) contribute to tumor development, with some acting as tumor suppressors and others as oncogenes.
View Article and Find Full Text PDFColorectal cancer (CRC) is a prevalent malignancy worldwide, driven by complex molecular mechanisms. This study aims to elucidate the role of lncRNAs within TGF-β pathway, a crucial signaling pathway in CRC progression, focusing specifically on their interaction with the SPP1 gene. We employed a multi-faceted approach, starting with comprehensive in silico analyses to identify candidate lncRNAs potentially involved in TGF-β pathway regulation.
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- Oral cancer (OC) is a significant global health issue, leading to many deaths, and early detection is vital for better patient outcomes.
- Advancements in DNA sequencing and transcriptome profiling have highlighted the role of non-coding RNAs (ncRNAs) in regulating genomic processes and signaling pathways, making them promising for clinical use.
- Combining spatial transcriptomics and metabolomics with single-cell RNA sequencing enhances our understanding of tumor environments, while exploring salivary biomarkers offers non-invasive diagnostic options for OC.
The (tripartite motif) family, with as a key member, plays a vital role in regulating health and disease. contains various functional domains essential for transcriptional regulation, primarily through its interaction with proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which impacts health and disease remain elusive.
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