Publications by authors named "M Enser"
Article Synopsis
- Pelvic bone and soft tissue sarcoma surgeries have a high risk of surgical site infections (SSIs), prompting a study to evaluate whether extending antibiotic prophylaxis (ABP) from the standard 24-48 hours to 5 days would lower this risk.
- The study analyzed data from 146 patients, revealing that 41% developed SSIs, with no significant difference in rates between those receiving extended ABP (46.4%) and standard ABP (39.8%).
- Key risk factors for developing SSIs included longer surgery duration, extended postoperative ICU stays, and use of specific surgical flaps, while the extended ABP did not show a benefit in reducing infections, which were most commonly polymicrobial.
Objectives: This study aimed at characterizing the pharmacokinetics (PK) of oral levofloxacin in adult patients in order to optimize dosing scheme and explore the PK/pharmacodynamics (PD) of levofloxacin in bone and joint infections (BJIs).
Methods: From November 2015 to December 2019, all patients hospitalized in Cochin Hospital, treated with levofloxacin and who had at least one dosage for therapeutic drug monitoring were included. PK was described using non-linear mixed-effect modelling.
Background: Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C should be 64-80 mg/L. This objective is based on clinical breakpoints and not on measured MIC.
View Article and Find Full Text PDFObjectives: One-stage replacement arthroplasty for treatment of periprosthetic joint infection (PJI) results in similar cure rate than two-stage (around 85-92%), but antibiotic therapy duration is not well established. The aim of this study was to evaluate the efficacy of a short six-week antibiotic course in periprosthetic joint infections after onstage exchange.
Patients And Methods: Retrospective, observational study conducted at Orthopaedic Department of Cochin Hospital, Paris, between 1st January 2010 and 31 December 2015.
Background: Noise, which is omnipresent in operating rooms and ICUs, may have a negative impact not only patients but also on the concentration of and communication between clinical staff.
Objective: The present study attempted to evaluate the impact of noise on the performance of anaesthesiology residents' clinical reasoning. Changes in clinical reasoning were measured by script concordance tests (SCTs).