Publications by authors named "M Engelbrecht"
Background: RECIST may not be optimal for assessing treatment response with current systemic regimens. We evaluated RECIST, morphologic, and pathologically documented response (pathological response) in patients with initially unresectable colorectal cancer liver-only metastases (CRLM).
Patients And Methods: Four hundred and eighty-nine patients from the phase III CAIRO5 trial were included who were treated with FOLFOX/FOLFIRI/FOLFOXIRI and bevacizumab or panitumumab.
Article Synopsis
- - The study investigates the reasons behind the limited involvement of male partners in maternal health (MPI), highlighting the importance of understanding various contributing factors.
- - Data were collected from 407 fathers through surveys and focus group discussions, revealing that over 60% had high levels of MPI, while younger age, unemployment, and lack of involvement in household duties were linked to lower MPI.
- - Qualitative findings indicated that relationship issues, family conflicts, and health system barriers also restrict male partner engagement in maternal health, emphasizing the need for health systems to adapt to socio-cultural practices.
Article Synopsis
- Patients with colorectal cancer and liver-only metastases showed improved outcomes when treated with FOLFOXIRI and bevacizumab compared to FOLFIRI and bevacizumab or with panitumumab, especially regarding progression-free survival and resection rates.
- The CAIRO5 trial involved 530 patients with initially unresectable liver metastases from colorectal cancer, evaluated across numerous centers in the Netherlands and Belgium, focusing on different treatment combinations based on tumor genetics.
- While more effective responses were observed with certain treatments, there was an increase in toxic side effects, particularly in specific genetic tumor variants like RAS/BRAFV600E.
Background: Despite compelling evidence of comorbidity between tuberculosis (TB) and depression, little is known about the prevalence and determinants of depression among TB patients in the Free State province in South Africa.
Objectives: This study assessed the prevalence and factors associated with possible depression among new drug susceptible TB patients attending primary health care facilities.
Method: The study followed a cross-sectional design.