Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype.

Diffuse large B-cell lymphoma (DLBCL) accounts for 40% of non-Hodgkin lymphoma, and 30% to 40% of patients will succumb to relapsed/refractory disease (rrDLBCL). Patients with rrDLBCL generally have low long-term survival rates due to a lack of efficient salvage therapies. Small-molecule inhibitors targeting the histone methyltransferase EZH2 represent an emerging group of novel therapeutics that show promising clinical efficacy in patients with rrDLBCL.

Investigation of Astaxanthin Effect on Cisplatin Ototoxicity in Rats by Using Otoacoustic Emission, Total Antioxidant Capacity, and Histopathological Methods.

Background: Cisplatin-induced ototoxicity is related to oxidative stress. Astaxanthin is one of the most powerful antioxidants in nature.

Aims/objectives: To investigate the protective effect of astaxanthin on cisplatin-induced ototoxicity.

Association between occurrence of ossicular chain defect and osteoprotegerin gene expression in patients with chronic otitis media.

Objective: Chronic otitis media (COM) is an important debilitating public problem causing hearing loss due to irreversible resorption of the ossicular chain. Activation of osteoprotegerin (OPG) during an acute attack of COM prevents bone resorption.The aim of the study was to investigate the role of OPG gene expression level on ossicular chain resorption in chronic otitis media.

The Moderating Role of Clique Hierarchical Organization on Resource Control by Central Clique Members.

Accessing resources in peer groups is essential for youth's survival and reproduction. To date, little is known about the behavioral strategies used by socially prominent preadolescent and early adolescent resource controllers in peer cliques, groups of individuals who hang out together during free time at school. Theory suggests that clique hierarchical organization should influence forceful resource control behavior of central (prominent) clique members, but evidence is mixed.

Peer Groups as a Context for School Misconduct: The Moderating Role of Group Interactional Style.

Peer group interactional style was examined as a moderator of the relation between peer group school misconduct and group members' school misconduct. Participants were 705 students (M  = 11.59 years, SD = 1.