Publications by authors named "M Emmert"
Regeneration after ischemia requires to be promoted by (re)perfusion of the affected tissue, and, to date, there is no therapy that covers all needs. In treatment with mesenchymal stem cells (MSC), the secretome acts via paracrine mechanisms and has a positive influence on vascular regeneration via proangiogenic factors. A lack of standardization and the high complexity of vascular structures make it difficult to compare angiogenic readouts from different studies.
View Article and Find Full Text PDFA novel, highly diastereoselective, and metal-free synthesis of multisubstituted piperidines via an S1 approach is reported in this study. The method allows for the preparation of highly functionalized compounds with exceptional diastereomeric selectivities and consistently reproducible yields. These compounds are of significant interest due to their remarkable biological activities toward influenza endonuclease.
View Article and Find Full Text PDFBackground: Cancer is the second most common cause of death in Germany, and treatment in certified cancer networks is recommended to ensure high-quality care. This study sought to (1) determine the percentage of all primary tumors that might potentially have been treated in certified cancer networks and (2) assess the development and current state of quality-assured cancer care for all cancer patients from a locally defined region in Upper Franconia, Germany.
Methods: This study was a population-centered retrospective cohort analysis based on data from the Bavarian Cancer Registry (2017-2023).
Article Synopsis
- - The study analyzed mid-term outcomes of 338 patients who underwent aortic valve replacement through right anterior thoracotomy, focusing on gender differences in outcomes across different age groups (≤60 and >60 years).
- - Women were found to be older and have a higher risk score (Euroscore II) compared to men, and although they had longer ICU stays and higher incidences of atrial fibrillation, overall mortality rates were low and similar between genders.
- - The findings suggest that tailored patient care and surgical approaches can mitigate the previously reported negative outcomes for women undergoing cardiac surgery, highlighting the importance of gender-specific considerations in treatment.
Article Synopsis
- The analysis aimed to compare patient outcomes from two large cohorts in Europe and the USA who underwent coronary artery bypass grafting (CABG) to assess the effectiveness of knowledge exchange among cardiovascular surgery societies.
- Data was collected from the European DuraGraft Registry (2,522 patients) and the US STS database (294,725 patients), with both groups undergoing CABG between 2016 and 2019, and factors were matched using propensity score models to ensure fair comparison of outcomes.
- Key findings revealed different patient profiles, with European patients more likely to have left main disease and receive arterial grafts, while US patients tended to have more saphenous vein grafts; however, these differences in treatment approaches were