dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa.

Retinitis pigmentosa (RP) is characterized by degeneration of rod and cone photoreceptors that progresses to irreversible blindness. Now, there are no mutation-agnostic approaches to treat RP. Here, we utilized a single adeno-associated virus (AAV)-based CRISPR activation system to activate phosphodiesterase 6B (Pde6b) to mitigate the severe degeneration in mice.

Enhancing Veterinary Education in Cambodia: Evaluation of Web-Based Resources in Teaching Herd Health and Epidemiology.

It can be challenging for veterinary schools in low- and middle-income countries (LMICs) to teach the 11 Competencies identified by the World Organisation for Animal Health (WOAH) due to inadequate faculty and teaching resources. This paper discusses the evaluation of web-based educational resources to support teaching in the Veterinary Faculty at the Royal University of Agriculture in Cambodia. Content- and pedagogy-based materials addressing herd health and epidemiology/disease investigation, their most urgent needs, were developed via a collaboration between Iowa State University, Ohio State University, and Massey University (New Zealand).

Clinical Characteristics and Treatment Outcomes in Unilateral Coats Disease: A Global Collaborative Study.

Purpose: To evaluate the clinical outcomes and prognostic factors in unilateral Coats disease in the era of anti-VEGF therapy.

Design: Global, multicenter, retrospective case series.

Subjects: Six hundred fifty-six eyes of 656 subjects with Coats disease were included in this study.