Publications by authors named "M Elizabeth Goff"
Background/objectives: A significant proportion of older adults with Alzheimer's disease or related disorders live in a long-term care facility. This study aimed to determine the time delay between admission and death for older adults with dementia.
Methods: A post hoc analysis was conducted using data from a French observational cohort, identifying older adults with dementia who were admitted to nursing homes.
Article Synopsis
- - Glycation is a process where proteins undergo a modification linked to conditions like diabetes, with specific products like glycated hemoglobin (HbA1c) being crucial for diabetes management and advanced glycation end-products (AGEs) associated with complications.
- - The study explores the use of fingernail clippings as a practical and non-invasive method to measure glycation levels over several months, utilizing liquid chromatography-mass spectrometry to quantify relevant biomarkers like furosine and AGEs.
- - Results show a moderate correlation between fingernail furosine levels and HbA1c, suggesting that fingernails can effectively reflect glycation levels similarly to blood tests, supporting their potential use in monitoring diabetes.
Article Synopsis
- Tumor hypoxia in pediatric malignant rhabdoid tumors (MRT) leads to resistance against radiation therapy, worsening treatment outcomes.
- Researchers repurposed an FDA-approved drug, Atovaquone (AVO), to reduce oxygen consumption in tumors, enhancing their sensitivity to low-dose radiation therapy.
- Using multispectral optoacoustic tomography (MSOT), they monitored oxygen levels in tumors, finding that AVO increased oxygen saturation before radiation treatment, which correlated with improved anti-tumor responses, while resistance to AVO diminished its effectiveness.
Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmissibility. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectins.
View Article and Find Full Text PDFIntroduction: In England, primary care networks (PCNs) offer opportunities to improve access to and sustainability of general practice through collaboration between groups of practices to provide care with a broader range of practitioner roles. However, there are concerns that these changes may undermine continuity of care. Our study investigates what the organisational shift to PCNs means for continuity of care.
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