Publications by authors named "M Elina Totaro"

Article Synopsis
  • The herbicide glyphosate effectively inhibits the enzyme EPSPS, highlighting the shikimate pathway as a target for developing new antimicrobial and herbicidal agents.
  • The final enzyme in this pathway, chorismate synthase (CS), was tested with various azo-dyes, leading to the identification of PH011669 as a significant inhibitor with specific dissociation and inhibition values.
  • The study utilized molecular docking and MD simulations to analyze how PH011669 interacts with CS, providing foundational insights for future development of novel enzyme inhibitors.
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Background: Osteoporosis and metabolic syndrome (MetS) are conditions associated with ageing and chronic inflammation; among MetS' components, visceral obesity has been correlated to low bone mineral density in postmenopausal women. However, data on an increased fracture risk in MetS are still contrasting. The trabecular bone score (TBS) is an indicator of bone quality and a potential predictive factor for fractures.

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Protein structure prediction and (re)design have gone through a revolution in the last 3 years. The tremendous progress in these fields has been almost exclusively driven by readily available machine learning algorithms applied to protein folding and sequence design problems. Despite these advancements, predicting site-specific mutational effects on protein stability and function remains an unsolved problem.

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Aim: The current study aimed to identify digital health literacy levels among nurses with respect to their education, role and attitude towards digital technologies.

Design: Cross-sectional study.

Methods: Through convenience sampling, all Registered Nurses, managers/leaders and nurse researchers employed in Hospitals, University Hospitals and Districts were recruited and surveyed using an online questionnaire.

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