Publications by authors named "M Eleftheriadou"
Article Synopsis
- Understanding cardiovascular risk factors like diabetes in vascular cells is challenging due to limited disease models.
- The review discusses the development of advanced 3D in vitro disease models using patient-derived stem cells, which better mimic human vascular issues compared to traditional 2D cultures.
- It highlights the importance of including various cell types in these models to accurately represent conditions like diabetic vasculopathy and suggests strategies for creating organ-specific models to study different vascular complications.
Article Synopsis
- Vascular complications are the leading cause of health issues and death related to diabetes, stemming from oxidative stress and metabolic problems.
- Mitochondrial dysfunction significantly contributes to issues in heart function and energy metabolism in diabetes, with non-coding RNAs and RNA-binding proteins potentially playing a role, though their specific impacts remain unclear.
- Using stem cell-based models can help researchers explore the relationship between non-coding RNAs, RNA-binding proteins, and mitochondrial dysfunction, which may lead to better treatments for diabetic vascular complications.
Background: Moorfields Eye Unit at the London Borough of Croydon sees over 47,000 outpatient attendances each year, 5894 of which attended the eye walk-in Urgent Care in the 2017- 2018 year, which has become unsustainable.
Methods: A recent audit found that referrers and patients had limited experience in managing ophthalmic conditions. If triaged according to clinical need only 22% patients attended required same-day hospital eye care.
Implantable drug delivery systems are an interesting alternative to conventional drug delivery systems to achieve local or systemic drug delivery. In this work, we investigated the potential of fused-deposition modelling to prepare reservoir-type implantable devices for sustained drug delivery. An antibiotic was chosen as a model molecule to evaluate the potential of this type of technology to prepare implants on-demand to provide prophylactic antimicrobial treatment after surgery.
View Article and Find Full Text PDFBackground: Isobutyryl-CoA dehydrogenase (IBD) is a mitochondrial enzyme catalysing the third step in the degradation of the essential branched-chain amino acid valine and is encoded by ACAD8. ACAD8 mutations lead to isobutyryl-CoA dehydrogenase deficiency (IBDD), which is identified by increased C4-acylcarnitine levels. Affected individuals are either asymptomatic or display a variety of symptoms during infancy, including speech delay, cognitive impairment, failure to thrive, hypotonia, and emesis.
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