Publications by authors named "M El Hachem"
Docosahexaenoic acid (DHA, C22:6 n-3), a predominant omega-3 polyunsaturated fatty acid in brain, plays a vital role in cerebral development and exhibits functions with potential therapeutic effects (synaptic function, neurogenesis, brain inflammation regulation) in neurodegenerative diseases. The most common approaches of studying the cerebral accretion and metabolism of DHA involve the use of stable or radiolabeled tracers. Although these methods approved kinetic modeling of ratios and turnovers for fatty acids, they are associated with excessive costs, restrictive studies, and singular dosing effects.
View Article and Find Full Text PDFSeveral studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases. Researchers principally studied the cerebral accretion of Lysophosphatidylcholine (LysoPC-DHA), the furthermost vital Lysophospholipid-DHA (LysoPL-DHA) in blood plasma. Nevertheless, the cerebral bioavailability of other LysoPL-DHA forms including Lysophosphatidylethanolamine (LysoPE-DHA), and Lysophosphatidylserine (LysoPS-DHA) were not extensively examined even though their vital biological functions in the brain.
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- * The study analyzed the fatty acid composition in the eyes of Arabian sheep and camels, finding that the retina had the highest levels of DHA and AA, with notable differences between the two species.
- * The research suggests that using ocular tissues from agri-food waste could be a sustainable method to produce beneficial fatty acids, impacting nutrition and healthcare.
Article Synopsis
- * The study found that glycosylation efficiencies for various polyphenols were significantly higher—up to 20.9 times—compared to non-complexed systems.
- * The research identified the rate-limiting step in the glycosylation process, showing that the enzyme's ability to open cyclodextrin was much more effective than its ability to glycosylate polyphenols, leading to an optimal yield of 84.1% for rutin.