Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies.

In B-cell malignancies, the overexpression of MYC is associated with poor prognosis, but its mechanism underlying resistance to immunochemotherapy remains less clear. In further investigations of this issue, we show here that the pharmacological inhibition of MYC in various lymphoma and multiple myeloma cell lines, as well as patient-derived primary tumor cells, enhances their susceptibility to NK cell-mediated cytotoxicity induced by conventional antibodies targeting CD20 (rituximab) and CD38 (daratumumab), as well as T cell-mediated cytotoxicity induced by the CD19-targeting bispecific T-cell engager blinatumomab. This was associated with upregulation of the target antigen only for rituximab, suggesting additional escape mechanisms.

Physical Health and Socioeconomic Status in Ambulatory Adults With Bilateral Spastic Cerebral Palsy.

Socioeconomic status (SES) tends to influence an individual's access to health care. It is commonly assumed that a poorer SES is associated with a weaker physical health status, especially in disadvantaged populations such as people with cerebral palsy (CP). However, to our knowledge, no study has looked at this assumption.

Investigation of thermal, acoustic, mechanical, and radiation shielding performance of waste and natural fibers.

It is crucial to address two pressing global issues, energy shortage and environmental pollution, when producing building insulation materials. Using waste and natural fiber groups can be part of the solution. The insulation material was produced using pumpkin fiber, chicken fiber, cotton waste, vermiculite, and epoxy as binders.

Incidence of respiratory infections and SARS-CoV-2 is higher during contact phases in student rugby players - Lessons learnt from COVID-19 risk mitigation strategies-AWARE V.

The incidence of acute respiratory infections (ARinf), including SARS-CoV-2, in unvaccinated student rugby players during phases from complete lockdown during the COVID-19 pandemic to returning to competition is unknown. The aim of the study was to determine the incidence of ARinf (including SARS-CoV-2) during non-contact and contact phases during the COVID-19 pandemic to evaluate risk mitigation strategies. In this retrospective cohort study, 319 top tier rugby players from 17 universities completed an online questionnaire.

Ankle, knee and concussion concerns: Unveiling injury patterns in highly trained South African netball players.

Objectives: To describe the rate and type of netball injuries sustained during women's university-level tournament matches in South Africa.

Design: Descriptive epidemiological study.

Setting: Three editions of the women's Varsity Netball tournament (2021-23).