Impact of hysterectomy on opioid use in patients with adenomyosis: A nationwide register study.

Introduction: Dysmenorrhea and heavy menstrual bleeding are the most common symptoms in adenomyosis, in addition to infertility and chronic pelvic pain. Hysterectomy is a common treatment for adenomyosis symptoms with curative effect on heavy menstrual bleeding but with less studied effects on pain reduction.

Material And Methods: This is a nationwide retrospective register-based cohort study including all hysterectomized patients with pathology-verified adenomyosis between 1 January 2012 and 31 December 2015 with a long-term follow-up three years pre- and three years postoperatively.

Atomistic Structure Investigation of Eu-Doped ZnO Nanosponges.

Zinc oxide (ZnO) is a semiconductor with a wide range of applications, and often the properties are modified by metal-ion doping. The distribution of dopant atoms within the ZnO crystal strongly affects the optical and magnetic properties, making it crucial to comprehend the structure down to the atomic level. Our study reveals the dopant structure and its contents in Eu-doped ZnO nanosponges with up to 20% Eu-O clusters.

Eco-friendly and strong lignin-containing microfibrillated cellulose films for high-performance separators of aqueous zinc batteries.

Aqueous zinc-ion batteries have gained significant interest, offering several distinct advantages over conventional lithium-ion batteries owing to their compelling low cost, enhanced battery safety, and excellent environmental friendliness. Nevertheless, the unfortunate growth of zinc dendrites during cycling leads to poor electrochemical performance of zinc batteries, primarily attributed to the diminished wet mechanical properties and limited electrolyte uptake of existing commercial separators. Herein, a bio-based separator was developed from sustainable resources using natural polymers derived from wood pulp to replace fossil-based polyolefin separators.

A combination of long- and short-read genomics reveals frequent p-arm breakpoints within chromosome 21 complex genomic rearrangements.

Purpose: Although chromosome 21 is the smallest human chromosome, it is highly relevant in the pathogenicity of both cancer and congenital diseases, including Alzheimer disease and trisomy 21 (Down syndrome). In addition, cases with rare structural variants (SVs) of chromosome 21 have been reported. These events vary in size and include large chromosomal events, such as ring chromosomes and small partial aneuploidies.

Multi-omics analysis detail a submicroscopic inv(15)(q14q15) generating fusion transcripts and MEIS2 and NUSAP1 haploinsufficiency.

Inversions are balanced structural variants that often remain undetected in genetic diagnostics. We present a female proband with a de novo Chromosome 15 paracentric inversion, disrupting MEIS2 and NUSAP1. The inversion was detected by short-read genome sequencing and confirmed with adaptive long-read sequencing.