Development of Deep Learning-Based Virtual Lugol Chromoendoscopy for Superficial Esophageal Squamous Cell Carcinoma.

Background: Lugol chromoendoscopy has been shown to increase the sensitivity of detection of esophageal squamous cell carcinoma (ESCC). We aimed to develop a deep learning-based virtual lugol chromoendoscopy (V-LCE) method.

Methods: We developed still V-LCE images for superficial ESCC using a cycle-consistent generative adversarial network (CycleGAN).

Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan.

Background: Three Janus kinase (JAK) inhibitors are approved for ulcerative colitis (UC) in Japan.

Aim: To compare the real-world efficacy and safety of these three JAK inhibitors in UC.

Methods: This was a multicentre, retrospective study of patients with UC started on JAK inhibitors.

A case of undifferentiated pleomorphic rectal sarcoma occurring after radiation exposure.

A 72 year-old man was referred to our hospital for a detailed examination of a recurrent rectal polyp. He had past histories of surgery and radiation therapy for prostate cancer at the age of 66 and endoscopic excision of a rectal polyp at the age of 70. Colonoscopy revealed a semi-pedunculated lesion surrounded by friable mucosa, which was positive under positron-emission tomography-computed tomography.

Appropriate leucine-rich α-2 glycoprotein cut-off value for Japanese patients with ulcerative colitis.

Background: It has been suggested that serum leucine-rich α-2 glycoprotein (LRG) could be a novel monitoring biomarker for the assessment of disease activity in inflammatory bowel disease. In particular, the relationship between LRG levels and the endoscopically assessed activity of ulcerative colitis (UC) has become a matter of interest.

Aim: To clarify appropriate LRG cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with UC.