Publications by authors named "M Ehlers"
Objectives: Clostridioides difficile infection is a serious healthcare-associated infection linked to antimicrobial use. The severity of the disease can be associated with hypervirulent ribotypes such as RT027. The study aimed to investigate the molecular epidemiology and genomic characteristics of C.
View Article and Find Full Text PDFKlebsiella pneumoniae multidrug-resistant (MDR) high-risk clones drive the spread of antimicrobial resistance (AMR) associated infections, resulting in limited therapeutic options. This study described the genomic characteristics of K. pneumoniae MDR high-risk clones in Gauteng, South Africa.
View Article and Find Full Text PDFThis study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with bla on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring bla including bla.
View Article and Find Full Text PDFEpidemiology and antimicrobial resistance profiles of pathogenic Escherichia coli from commercial swine and poultry abattoirs and farms in South Africa: A One Health approach.
Sci Total Environ
November 2024
Article Synopsis
- Pathogenic Escherichia coli (PEC) can cause severe illness in humans and are commonly found in the intestines of animals and humans, contaminating food and water through faecal transmission.
- A study in South Africa collected samples from swine, poultry, human hand swabs, and water to analyze the prevalence and resistance patterns of PEC, finding that certain serogroups were predominant and many isolates showed multi-drug resistance (MDR).
- The results emphasize the risk of these pathogens spreading through close human contact and the necessity for improved monitoring to control MDR foodborne PECs in communities.
Article Synopsis
- A study identified a multidrug-resistant strain of Pseudomonas aeruginosa AUST-03 (ST242) in South African children with cystic fibrosis, linking it to increased health risks.
- Whole genome sequencing revealed a high prevalence of specific antibiotic resistance genes in these isolates, with significant genetic similarities to a global isolate from Russia.
- The findings highlight the urgent need for effective infection control measures in public clinics to prevent outbreaks of this resistant strain.