Publications by authors named "M Ecay-Torres"
Article Synopsis
- Alzheimer's disease is a progressive condition that requires early detection for effective treatment but currently relies on expensive and invasive diagnostic methods.
- This study introduces label-free Raman spectroscopy combined with machine learning as a new approach for diagnosing preclinical Alzheimer's by analyzing cerebrospinal fluid samples for specific molecules like nucleic acids and proteins.
- The resulting model shows strong reliability across different patient cohorts and time periods, demonstrating Raman spectroscopy's potential for non-invasive Alzheimer's diagnosis and promising future clinical application.
Background: GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evaluate the feasibility and adherence to a FINGER-like multidomain intervention program. Additional aims included the assessment of efficacy on cognition and data collection to design a large efficacy trial.
Method: GOIZ ZAINDU is a 1-year, randomized, controlled trial of a multidomain intervention in persons aged 60+ years, with Cardiovascular Risk Factors, Aging and Dementia (CAIDE) risk score ≥ 6, no diagnosis of dementia, and below-than-expected performance in at least one of three cognitive screening tests.
Brief cognitive tests as a decision-making tool in primary care. A population and validation study.
Neurologia (Engl Ed)
December 2024
Introduction And Objectives: Brief cognitive tests (BCT) are used in primary care (PC) for the detection of cognitive impairment (CI). Still, there are little data on their diagnostic utility (DU) in a community setting. This work evaluates the DU at the population level of Fototest, T@M, AD8 questionnaire and MMSE.
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- The study aimed to investigate accelerated long-term forgetting (ALF) in cognitively unimpaired individuals, focusing on those with subjective cognitive decline (SCD) and the link to Alzheimer's disease biomarkers in cerebrospinal fluid (CSF).
- Fifty-two participants were categorized based on their SCD levels using the Subjective Cognitive Decline Questionnaire (SCD-Q) and further divided by the presence of abnormal CSF Aβ levels.
- Results indicated that individuals with high SCD-Q scores experienced greater forgetting rates, especially those with abnormal Aβ levels, suggesting a need for more rigorous cognitive testing in both research and clinical settings.
Accelerated long-term forgetting over three months in asymptomatic APOE ɛ4 carriers.
Ann Clin Transl Neurol
February 2021
Article Synopsis
- Accelerated long-term forgetting (ALF) is a rapid loss of information that can occur within days or weeks, even when information is normally learned.
- This study focused on comparing ALF in individuals who carry the APOE ɛ4 gene, which is linked to Alzheimer's disease, to those who do not carry the gene, while also checking for connections to Alzheimer's biomarkers in cerebrospinal fluid (CSF).
- Results showed that APOE ɛ4 carriers experienced significant ALF over three months, and this was correlated with abnormal levels of Aβ/ptau ratios in CSF, suggesting ALF may indicate early signs of cognitive decline related to Alzheimer's disease.