Publications by authors named "M Eaaswarkhanth"
Article Synopsis
- Androgenetic alopecia, or male pattern baldness, is largely influenced by genetics, but most research has focused on individuals of European descent.
- A study of 2,136 men from Ghana, Nigeria, Senegal, and South Africa found that genetic predictions for baldness based on European data were less accurate for African populations.
- The first African genome-wide association study (GWAS) identified 266 genetic associations with baldness, showing that most genetic influences are autosomal and that evolutionary history affects genetic predictions across different ancestries.
The potential role of the salivary microbiome in human diseases has increasingly been explored. The salivary microbiome has been characterized in several global populations, except the Arabian Gulf region. Hence, in this pilot study, we profiled the salivary microbiome of Kuwaiti adolescents with varied body mass indexes (BMI).
View Article and Find Full Text PDFRecent studies have showed the diverse genetic architecture of the highly consanguineous populations inhabiting the Arabian Peninsula. Consanguinity coupled with heterogeneity is complex and makes it difficult to understand the bases of population-specific genetic diseases in the region. Therefore, comprehensive genetic characterization of the populations at the finest scale is warranted.
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- Whole-exome sequencing was used to analyze genetic variations related to obesity in a group of 288 native Arabs in Kuwait, revealing mitochondrial DNA's role in obesity risk.
- Variants and haplogroups were identified, showing that haplogroup R decreases obesity risk while haplogroup L increases it; significant differences in mitochondrial mutations between obese and non-obese groups were also noted.
- Findings confirm the effectiveness of whole-exome sequencing in studying mitochondrial haplogroups and their association with obesity for the first time in this specific population.
The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly variable in different global populations. SARS-CoV-2 uses as a cell receptor, protease, and peptidase to invade human cells. Here, we investigated 1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait, Qatar, and Iran) to explore natural variations in the , and genes.
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