Application of vesicles to rat skin in vivo: a confocal laser scanning microscopy study.

A major problem in (trans)dermal drug delivery is the low penetration rate of most substances through the barrier of the skin, the stratum corneum. One of the methods to increase the penetration rate across the skin is encapsulation of a (model) drug in lipid vesicles. In this study fluorescently labelled liposomes were applied on rat skin, in vivo.

Interactions between liposomes and human skin in vitro, a confocal laser scanning microscopy study.

One major problem in (trans)dermal drug delivery is the low penetration rate of drugs through the barrier of the skin. Encapsulation of a drug in lipid vesicles is one strategy to increase the penetration rate of a drug across the skin. In this study, the interactions between fluorescent-labelled liposomes and skin are visualized by confocal laser scanning microscopy (CLSM).

Human recombinant apolipoprotein E-enriched liposomes can mimic low-density lipoproteins as carriers for the site-specific delivery of antitumor agents.

Progressive hypocholesterolemia is a feature associated with a number of cancers of different origin, and it is caused by the high expression of low-density lipoprotein (LDL) receptors (LDLrs) on many tumor cell types. Selective delivery of chemotherapeutics using LDL as a carrier has therefore been proposed, but the endogenous nature of LDL hampers its pharmaceutical application. In the current study, we explored the possibility of synthesizing liposomes that mimic LDL from commercially available lipids and proteins.