Publications by authors named "M E Warchol"
Light-emitting diode (LED) lamps are efficient elicitors of secondary metabolites. To investigate the influence of LED light on steviol glycosides (SGs) and phenolic compounds biosynthesis, stevia shoots were cultured under the following LED lights: white-WL, blue-B, red-R, 70% red and 30% blue-RB, 50% UV, 35% red and 15% blue-RBUV, 50% green, 35% red and 15% blue-RBG, 50% yellow, 35% red and 15% blue-RBY, 50% far-red, 35% red and 15% blue-RBFR and white fluorescent light (WFl, control). RBG light stimulated shoots' biomass production.
View Article and Find Full Text PDFPurpose: Developing innovative precision and personalized cancer therapeutics is essential to enhance cancer survivability, particularly for prevalent cancer types such as colorectal cancer. This study aims to demonstrate various approaches for discovering new targets for precision therapies using artificial intelligence (AI) on a Polish cohort of colorectal cancer patients.
Methods: We analyzed 71 patients with histopathologically confirmed advanced resectional colorectal adenocarcinoma.
Article Synopsis
- Cisplatin, a chemotherapy drug, leads to irreversible hearing loss by damaging cochlear hair cells, with mitochondrial activity playing a crucial role in this process.
- * Researchers used zebrafish to show that increased redox history heightens hair cell vulnerability to cisplatin, and observed significant changes in mitochondrial and calcium levels before hair cell death.
- * The study found that cisplatin accumulates specifically in hair cell mitochondria prior to causing mitochondrial dysfunction, highlighting the mitochondria's essential role in the drug's toxic effects.*
Pollution of arable land with heavy metals is a worldwide problem. Cadmium (Cd) is a toxic metal that poses a severe threat to humans' and animals' health and lives. Plants can easily absorb Cd from the soil, and plant-based food is the main means of exposure to this hazardous element for humans and animals.
View Article and Find Full Text PDFCisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses. To investigate the roles of macrophages in cisplatin-induced toxicities, we used PLX3397, a U.
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