Publications by authors named "M E Valieva"
Article Synopsis
- Researchers developed a new ligand (called probe 12) based on 4-methoxyphenyl-2,2'-bipyridine that can detect zinc through fluorescence, showing a significant increase in brightness when zinc is present.
- Probe 12 has a high binding affinity for zinc, with a binding constant of approximately 2 × 10^6 M⁻¹ and a limit of detection at around 0.1 nM, outperforming a previously known probe.
- The effectiveness of probe 12 for zinc detection was confirmed through various methods, and it proved capable of identifying zinc in both live cells and fixed tissues, specifically highlighting pancreatic beta cells.
A series of α-cycloamine substituted 2,2'-bipyridines 3ae'-3ce' was obtained via the one-pot approach based on ipso-substitution of a cyano-group in 1,2,4-triazines, followed by aza-Diels-Alder reaction in good yields. Photophysical properties, including fluorosolvatochromism, were studied for 3ae'-3ce' and were compared with α-unsubstituted 2,2'-bipyridines. In addition, dipole moments differences in ground and excited states were calculated by both Lippert-Mataga equation and DFT studies and were compared to each other.
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- A total of 21 new xanthone and acridone compounds were created through specific chemical reactions involving triazine derivatives and acridone/xanthone derivatives, followed by optional ring aromatization.
- Five of these compounds showed promising anticancer effects against several types of cancer cells, including colorectal and glioblastoma.
- Notably, certain compounds exhibited low toxicity to normal kidney cells, indicating their potential for further development as cancer treatments, with one compound activating apoptotic mechanisms in glioblastoma cells.
New Tb(III) and Eu(III) complexes based on aryl-2,2'-bipyridine ligands with a cyclic DO3A chelating unit appended in the alpha position of the bipyridine core were synthesized. The photophysical properties of these complexes were compared with those of complexes of ligands with identical aryl-2,2'-bipyridine chromophores, but with an acyclic DTTA residue as an additional chelating site in the alpha position of the bipyridine core. The nature of the polyaminocarboxylic acid fragments was found to have a significant influence on the luminescence.
View Article and Find Full Text PDFThis paper reports the synthesis of four types of annulated pyranoindole congeners: pyrano[3,2-]indole, pyrano[2,3-]indole, pyrano[2,3-]indole, and pyrano[2,3-]indole and photophysical studies in this series. The synthesis of pyrano[3,2-], [2,3-], and [2,3-]indoles involve a tandem of Bischler-Möhlau reaction of 3-aminophenol with benzoin to form 6-hydroxy- or 4-hydroxyindole followed by Pechmann condensation of these hydroxyindoles with β-ketoesters. Pyrano[2,3-]indoles were synthesized through the Nenitzescu reaction of -benzoquinone and ethyl aminocrotonates and subsequent Pechmann condensation of the obtained 5-hydroxyindole derivatives.
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