[Age characteristics of primary disability of adult population due to diseases of digestive organs in the Belgorod region during 2010-2018.].

The analysis of indicators of primary disability due to diseases of digestive organs among pension age and working-age population of the Belgorod region is carried out in comparative aspect with the national indicators during 8 years. Rank places of diseases of digestive organs in structure of primary disability were defined. The revealed main features and trends of disability, were investigated to further optimization of medico-social service and improved support to this contingent of disabled people.

[Gerontological aspects of the demographic situation in the Belgorod region, 2010-2018.].

In the Belgorod region during 2010-2018 the total number of the population slightly increased by 1,3%, until 2017 only because of migratory gain. After 2018 it does not compensate natural decrease of the population. During the analyzed period from 2010 to 2018 the negative demographic trends which are characterized by depopulation owing to decrease in birth rate, growth of mortality and ageing of the population took place.

[Comparative analysis of serum analyte level measurements by commercial diagnostic kits from four manufacturers (Alkor-Bio, Roche, Diagnostic Products Corporation-DCP, and Bayer Corporation)].

Hydrocortisone, progesterone, testosterone, triiodothyronine, thyroxine, chorionic gonadotropin, prolactin, alpha-fetoprotein, luteinizing, follicle-stimulating, and thyrotropic hormones were measured in human sera and in Lyphochek Immunoassay Plus Control reference sera (Bio-Rad Laboratories, USA) using 4 commercial kits (Alkor Bio Inc. and Roche, automated analyzer Roche Cobas Core; DPC, automated analyzer Immulite; Bayer, automated analyzer ACS:180). Coordination and correlation between these kits was observed, the coordination decreasing in the series Alkor Bio/Bayer, Alkor Bio/Roche, and Alkor Bio/DPC.

Alu-DNA repeat-binding protein p68 is a part of Alu-RNA containing alpha-RNP.

An Alu-DNA repeat-binding protein with a molecular mass of 68 kDa (p68) is identified in the somatic human cell nucleoplasm. Gel mobility shift assay (GMSA), South-western blotting and affinity purification on DNA attached to the carrier were used in the identification. GMSA revealed multiple complexes with the exponential dependence of their relative mobility.