Publications by authors named "M E Troiani"
Article Synopsis
- The study investigates how coagulation factor X (FX) impacts tumor growth in castration-resistant prostate cancer (CRPC) by examining the prostate tumor microenvironment in mouse models through single-cell RNA sequencing.
- It finds that immunosuppressive neutrophils (PMN-MDSCs) produce FX, which activates pathways that enhance tumor cell growth independent of androgens, indicating a role for FX in cancer progression.
- Targeting FXa could impede the oncogenic function of PMN-MDSCs and potentially improve treatment outcomes when combined with existing therapies, with high levels of FX and related markers correlating to worse survival in CRPC patients.
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy. Consequently, the clinical challenge lies in developing therapies that safely enhance senescence in cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones.
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- The human body is home to trillions of tiny creatures called microorganisms, which affect our health and can play a role in diseases like cancer.
- Some studies found that certain gut and urinary bacteria might increase the risk of prostate cancer and are linked to changes in specific genes that can lead to cancer.
- New research suggests that understanding and changing these bacteria could help in detecting and treating prostate cancer, using methods like probiotics or faecal transplants to improve patient care.
Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently available immunotherapies do not completely eradicate MDSCs. Through a genome-wide analysis of the translatome of prostate cancers driven by different genetic alterations, we demonstrate that prostate cancer rewires its secretome at the translational level to recruit MDSCs.
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