Publications by authors named "M E Sumner"
Two trials were performed to evaluate the effect of renal and hepatic impairment on the pharmacokinetics of pritelivir and its metabolites. The renal impairment trial included subjects with mild, moderate, and severe impairment, while the hepatic impairment trial included subjects with moderate impairment. Both trials recruited a matched control group of healthy subjects.
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- The study aimed to evaluate the relationship between social behaviors and SARS-CoV-2 test positivity in children under 18 years old during 2020-2022, using data from emergency departments.
- It found that attending social gatherings increased the chances of testing positive for SARS-CoV-2 in children aged 5-<12 years while in-person daycare/school attendance was linked to a lower risk of positivity across all age groups.
- Key findings indicated that children's risk of infection was influenced by factors like mask-wearing and exposure to infected contacts, with settings like schools promoting better public health practices, thus lowering risk.
Pritelivir is a novel viral helicase-primase inhibitor active against herpes simplex virus. In vitro drug-drug interaction studies indicated that pritelivir has the potential for clinically relevant interactions on the cytochrome P450 (CYP) enzymes 2C8, 2C9, 3A4, and 2B6, and intestinal uptake transporter organic anion transporting polypeptide (OATP) 2B1 and efflux transporter breast cancer resistance protein (BCRP). This was evaluated in 2 clinical trials.
View Article and Find Full Text PDFBackground: Acyclovir-resistant mucocutaneous herpes simplex virus (HSV) infection is an uncommon problem typically seen in immunocompromised hosts. Systemic treatment options are limited. The performance of foscarnet and its toxicities in this population are poorly characterized.
View Article and Find Full Text PDFThe discovery that listeners more accurately identify words repeated in the same voice than in a different voice has had an enormous influence on models of representation and speech perception. Widely replicated in English, we understand little about whether and how this effect generalizes across languages. In a continuous recognition memory study with Hindi speakers and listeners (N = 178), we replicated the talker-specificity effect for accuracy-based measures (hit rate and D'), and found the latency advantage to be marginal (p = 0.
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