Publications by authors named "M E Stryjewski"
Article Synopsis
- Contezolid is a new type of antibiotic that shows promise for treating certain skin infections in people with diabetes.
- It comes in two forms: one is taken by mouth, and the other is given through an IV.
- The study helps figure out the best way to use these medicines safely and effectively by looking at how they work in the body for both healthy volunteers and patients.
Background: Ceftobiprole is a cephalosporin that may be effective for treating complicated bacteremia, including methicillin-resistant .
Methods: In this phase 3, double-blind, double-dummy, noninferiority trial, adults with complicated bacteremia were randomly assigned in a 1:1 ratio to receive ceftobiprole at a dose of 500 mg intravenously every 6 hours for 8 days and every 8 hours thereafter, or daptomycin at a dose of 6 to 10 mg per kilogram of body weight intravenously every 24 hours plus optional aztreonam (at the discretion of the trial-site investigators). The primary outcome, overall treatment success 70 days after randomization (defined as survival, bacteremia clearance, symptom improvement, no new bacteremia-related complications, and no receipt of other potentially effective antibiotics), with a noninferiority margin of 15%, was adjudicated by a data review committee whose members were unaware of the trial-group assignments.
Article Synopsis
- Carbapenem-resistant Acinetobacter baumannii (CRAb) is a major concern in antimicrobial resistance, with a study conducted on 842 hospitalized patients from 46 hospitals across five regions to assess its clinical impact and epidemiology between 2017 and 2019.
- The study found that 64% of the cases were infections, with a 30-day mortality rate of 24% among infected patients, highlighting notable regional differences in mortality rates.
- Additionally, both bloodstream infections and higher comorbidity were linked to increased mortality, while the dominant clonal group (CG2) was prevalent but non-CG2 strains resulted in higher death rates despite lower resistance to treatment.
[Comparative analysis of clinical characteristics, evolution and mortality of hospitalized patients with COVID-19 during the first and second wave of the pandemic (ECCOVID Study)].
Medicina (B Aires)
August 2023
Introduction: Clinical features and outcomes of SARSCoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina.
Methods: Multicenter and prospective registry of patients =18 years old with a confirmed diagnosis of COVID-19 admitted to 18 hospitals in Argentina during the first wave (March to October 2020) and second wave (March to July 2021) of the pandemic.
Asymptomatic infections with SARS-CoV-2 are associated with viral transmission and have a key role in the propagation of the pandemic. Understanding viral shedding during asymptomatic infections is critical. Unfortunately, data on asymptomatic SARS-CoV-2 infection in children is extremely limited.
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