Publications by authors named "M E Stillabower"
Article Synopsis
- The CERTAINTY study aims to improve the identification of individuals at low risk for ventricular arrhythmia (VA) among those who may need implantable cardioverter-defibrillators (ICDs) to reduce complications.* -
- This study utilizes deep learning techniques to analyze cine cardiac magnetic resonance (CMR) images, developing two neural networks: one for extracting cardiac features (Cine Fingerprint Extractor) and another for predicting VA risk (Risk Predictor).* -
- Findings show that a cine risk score derived from CMR images effectively differentiates between patients with and without VA, suggesting that cine CMR can enhance risk predictions in patients being considered for primary prevention ICDs.*
Background Current approaches fail to separate patients at high versus low risk for ventricular arrhythmias owing to overreliance on a snapshot left ventricular ejection fraction measure. We used statistical machine learning to identify important cardiac imaging and time-varying risk predictors. Methods and Results Three hundred eighty-two cardiomyopathy patients (left ventricular ejection fraction ≤35%) underwent cardiac magnetic resonance before primary prevention implantable cardioverter defibrillator insertion.
View Article and Find Full Text PDFBackground: Left ventricular ejection fraction (LVEF) improves over time in 25%-40% of patients with cardiomyopathy with primary prevention implantable cardioverter-defibrillator (ICD). The determinants of LVEF improvement, however, are not well characterized.
Objectives: We sought to examine the associations of clinical risk factors and cardiac imaging markers with changes in LVEF after ICD implantation.
1. Cyclo-oxygenase-2 (COX-2)-derived prostaglandins are important in controlling sodium excretion and renin release. In the present study, we tested the hypothesis that a clinical dose of celecoxib would impair urinary sodium excretion and elevate blood pressure (BP) during dietary salt loading.
View Article and Find Full Text PDFContext: High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined.
Objective: To evaluate the effect of high-dose compared with standard-dose clopidogrel in patients with high on-treatment platelet reactivity after PCI.
Design, Setting, And Patients: Randomized, double-blind, active-control trial (Gauging Responsiveness with A VerifyNow assay-Impact on Thrombosis And Safety [GRAVITAS]) of 2214 patients with high on-treatment reactivity 12 to 24 hours after PCI with drug-eluting stents at 83 centers in North America between July 2008 and April 2010.