One-pot reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate: an efficient approach to highly functionalized 1,6-dihydropyridine derivatives.

In this work, we present an efficient strategy for the straightforward synthesis of functionalized 1,6-dihydropyridine derivatives a three-component reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate. A tandem procedure including NH aldimine formation/Michael-type addition/opening of the pyrone ring/isomerization/6π-electrocyclization/[1,5]-H shift allows rapid access to a series of dihydropyridines bearing an -hydroxybenzoyl and a benzoyl scaffold in good yields. Readily available precursors, simple heating conditions, and operational simplicity are some highlighted advantages of this transformation.

Enhanced antimicrobial effects of carvacrol against methicillin-resistant Staphylococcus aureus strains using niosome formulations.

Methicillin-resistant Staphylococcus aureus (MRSA) causes a wide range of infections and contributes to elevated morbidity, mortality, and healthcare costs. Herbal compounds combined with drug delivery systems could be an effective alternative option for treating resistant bacteria. This study evaluates the antimicrobial prowess of carvacrol-loaded niosomes against MRSA strains.

Genetic analysis and association detection of agronomic traits in maize genotypes.

In maize breeding, enhancing yield through genetic insights is crucial yet challenged by the complex interplay of agronomic traits. This study utilized a diallel mating design involving nine advanced early maize lines to dissect the genetic architecture underlying key agronomic traits and their impact on yield. Over two consecutive years (2018-2019 and 2019-2020), 36 hybrids derived from these lines were grown across two locations, Karaj, Alborz, Iran and Kermanshah (2019-2020), Iran, in a randomized complete block design with three replications.

Functional and Structural Improvement of Engineered Cardiac Microtissue Using Aligned Microfilaments Scaffold.

To enhance therapeutic strategies for cardiovascular diseases, the development of more reliable in vitro preclinical systems is imperative. These models, crucial for disease modeling and drug testing, must accurately replicate the 3D architecture of native heart tissue. In this study, we engineered a scaffold with aligned poly(lactic--glycolic acid) (PLGA) microfilaments to induce cellular alignment in the engineered cardiac microtissue (ECMT).

A comprehensive scheme for power management of FC/SC/battery, and solar-roof PV source in electric vehicle systems.

This paper proposes a new energy management system to combine Fuel Cells (FC) and photovoltaic (PV) panels as primary power sources. Also, battery and Super Capacitor (SC) banks are considered as secondary energy systems. The high power density and the fast dynamics of SCs combined with the high energy density and medium dynamics of batteries would be an ideal combination for FC vehicles.