Publications by authors named "M E Shipley"
Herpes simples virus 1 (HSV-1) keratitis is a major cause of blindness globally. During primary infection, HSV-1 travels to the trigeminal ganglia and establishes lifelong latency. Although some treatments can reduce symptom severity and recurrence, there is no cure for HSV-1 keratitis.
View Article and Find Full Text PDFObjective: We hypothesise that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.
Design: Longitudinal cohort study.
Setting: Civil service departments in London (Whitehall II study).
Prognostic Significance and Associations of Neural Network-Derived Electrocardiographic Features.
Circ Cardiovasc Qual Outcomes
December 2024
Article Synopsis
- The study explores the use of advanced neural network-derived ECG features to predict cardiovascular disease and mortality, aiming to uncover subtle, important indicators that traditional methods might miss.
- Using data from over 1.8 million patients and various international cohorts, researchers identified three distinct phenogroups, with one, phenogroup B, showing a significantly higher mortality risk—20% more than phenogroup A.
- The findings suggest that neural network ECG features not only indicate future health risks like atrial fibrillation and ischemic heart disease but also highlight specific genetic loci that may contribute to these risks.
Article Synopsis
- - After HSV-1 virus enters host cells, its genome quickly becomes heterochromatinized, limiting viral gene expression, but it needs to de-repress this chromatin for effective replication.
- - The HSV-1 genome has encoded CTCF insulators that are crucial for regulating the transcription of immediate early (IE) genes throughout the virus's life cycle, with a specific focus on the CTRL2 insulator linked to gene silencing during latency.
- - Research using a recombinant virus lacking the CTRL2 insulator revealed that this absence led to reduced gene expression and replication defects, as increased repressive histone markers around the IE gene regions hindered chromatin accessibility during early infection stages.
Purpose: To describe program characteristics and outcomes of a residential substance use recovery program serving pregnant and parenting women in a rural and urban location.
Description: This assessment of administrative records from April 1, 2020 through March 31, 2022, included women in a rural (n = 140) and urban (n = 321) county in Kentucky.
Assessment: This retrospective case study used descriptive and non-parametric analyses to assess the population and examine differences between locations, race, and ethnicity for women served.