Publications by authors named "M E Schaner"
Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most are unknown. We conducted the largest disease-focused expression quantitative trait loci (eQTL) analysis using colon tissue from 252 IBD patients to determine genetic effects on gene expression and potential contribution to IBD. Combined with two non-IBD colon eQTL studies, we identified 194 potential target genes for 108 GWAS loci.
View Article and Find Full Text PDFBackground And Aims: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflammation. Here, we investigated how DNA methylation of the tumor necrosis factor (TNF) promoter differs between inflamed and uninflamed mucosa of IBD patients, including anti-TNF responders and nonresponders.
View Article and Find Full Text PDFArticle Synopsis
- Crohn's disease (CD) is a long-lasting GI disorder that leads to complications requiring surgery, with many patients facing post-operative issues and disease recurrence despite medical advances.
- This study analyzed gene expression data from 45 CD patients to explore common genes and pathways linked to post-operative complications and disease recurrence, using techniques like gene set enrichment analysis and logistic regression.
- Results showed certain inflammatory pathways were raised in recurrent cases and septic complications, while a decrease in myogenesis in colon tissue linked both outcomes, highlighting potential biomarkers for improving patient management.
Crohn's disease (CD) is a chronic inflammatory gut disorder. Molecular mechanisms underlying the clinical heterogeneity of CD remain poorly understood. MicroRNAs (miRNAs) are important regulators of gut physiology, and several have been implicated in the pathogenesis of adult CD.
View Article and Find Full Text PDFBackground And Aims: Inflammatory Bowel Diseases (IBD) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflammation. Here, we investigated how DNA methylation of the promoter differs between inflamed and uninflamed mucosa of IBD patients, including anti-TNF responders and non-responders.
View Article and Find Full Text PDF