Study of the stress proteins secreted by Leishmania donovani after treatment with edelfosine, mitelfosine and ilmofosine, and morphological alterations analyzed by electronic microscopy.

We studied the stress proteins induced in protozoa Leishmania donovani after treatment with edelfosine, miltefosine and ilmofosine. We studied the morphological and structural modifications caused in the promastigote forms of the parasite after treatment with the three alkyl-lysophospholipids (ALPs). A resistant strain of L.

Echinococcus granulosus and other intestinal helminths in semi-stray dogs in Tunisia: infection and re-infection rates.

Objective: Assessing the baseline prevalence and the re-infection rate of E. granulosus and other cestodes in dogs is important for a control program based on regular dog dosing treatment with praziquantel mainly to young rural dogs.

Methods: Three hundred and seventy five rural and semi-stray dogs from Jendouba (207 dogs) and Béjà (168 dogs) Departments in Northern-West of Tunisia, were examined to evaluate both the baseline prevalence of intestinal helminths and re-infection rates with Echinococcus granulosus and other cestodes.

An oral recombinant vaccine in dogs against Echinococcus granulosus, the causative agent of human hydatid disease: a pilot study.

Dogs are the main source of human cystic echinococcosis. An oral vaccine would be an important contribution to control programs in endemic countries. We conducted two parallel experimental trials in Morocco and Tunisia of a new oral vaccine candidate against Echinococcus granulosus in 28 dogs.

Molecules targeting the purine salvage pathway in Apicomplexan parasites.

The need of intracellular parasites to retrieve nutrients and fulfill their energy requirements is achieved by manipulating the host's metabolism. With the spread of AIDS, research on purine metabolism has gained in importance with the aim to develop drugs against opportunistic infections. Many studies over the past ten years have yielded contradictory results, but this review tries to clarify these findings by exposing the latest data concerning purine transport and the specific activities of the major enzymes of the purine salvage pathway of Toxoplasma gondii, Plasmodium falciparum and Cryptosporidium parvum.