Publications by authors named "M E Sakuma"
Objectives: Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant tumors. Therefore, we investigated the anticancer and antiangiogenic effects of LEF on oral squamous cell carcinoma (OSCC).
Methods: To evaluate the inhibitory effect of LEF on OSCC, cell proliferation and wound-healing assays using human OSCC cell lines were performed.
In tissues, neutrophils neutralize Candida albicans through phagocytosis and delay C. albicans hyphae growth by deploying neutrophil extracellular traps (NETs). However, in the bloodstream, the dynamic interactions between NETs and C.
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- This study investigates the cost-effectiveness of using mechanical thrombectomy (MT) alongside standard medical care (SMC) for patients aged 90 and older suffering from acute ischemic stroke (AIS).
- A simulation model estimated that MT with SMC provided 1.463 quality-adjusted life years (QALYs) at a cost of 14,553,772 Yen, compared to 1.054 QALYs for SMC alone, which cost 13,732,646 Yen.
- The findings suggest that the incremental cost-effectiveness ratio (ICER) of MT with SMC is 2,009,744 Yen per QALY, indicating a 66% chance that this approach