Publications by authors named "M E Ryan"
Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little is known about the function and regulation of most of these sites. A major challenge has been producing recombinant phospho-proteins in order to test the effects of phosphorylation.
View Article and Find Full Text PDFObjective: To better understand critically ill children's lived experiences with family presence in the pediatric intensive care unit (PICU).
Study Design: This qualitative, interpretive phenomenological study is grounded in a Childhood Ethics ontology. We recruited children (aged 6-17 years) admitted to one of four participating Canadian PICUs between November 2021-July 2022 using maximum variation sampling.
Article Synopsis
- The study aimed to evaluate the pediatric Brain Injury Guidelines (pBIG) for identifying pediatric patients with traumatic intracranial hemorrhage (ICH) who may not need further neuroimaging or hospitalization.
- A total of 955 patients were analyzed, with findings showing that the majority had pBIG 2 or 3 injuries, and nearly 40% of those who had repeat imaging showed hemorrhage progression.
- Those meeting pBIG 3 criteria were significantly more likely to need surgical intervention or face higher mortality rates, emphasizing the importance of the guidelines in determining treatment urgency.
The remediation of antimicrobial resistance (AMR) is a fundamental challenge for global healthcare. Intrinsically disordered proteins (IDPs) are recognized drug targets for neurodegeneration and cancer but have not been considered to date for AMR. Here, a novel link between structural disorder and AMR is identified by mapping predicted disorder profiles onto existing transcriptomic data for resistant and susceptible isolates.
View Article and Find Full Text PDFAims: Prolonged waits for hip and knee arthroplasty have raised questions about the equity of current approaches to waiting list prioritization for those awaiting surgery. We therefore set out to understand key stakeholder (patient and surgeon) preferences for the prioritization of patients awaiting such surgery, in order to guide future waiting list redesign.
Methods: A combined qualitative/quantitative approach was used.