National biodiversity data infrastructures: ten essential functions for science, policy, and practice.

Today, at the international level, powerful data portals are available to biodiversity researchers and policymakers, offering increasingly robust computing and network capacities and capable data services for internationally agreed-on standards. These accelerate individual and complex workflows to map data-driven research processes or even to make them possible for the first time. At the national level, however, and alongside these international developments, national infrastructures are needed to take on tasks that cannot be easily funded or addressed internationally.

Toward Decision Support System for Lower Limb Endovascular Revascularization.

Vascular surgeons take decisions on the revascularization technics when surgery is needed for patients with Lower Extremities Arterial Disease (LEAD). This decision requires experience, good knowledge of official recommandations and new technics and an exhaustive description of the patient status. The Case Based Reasoning (CBR) is a good candidate to clinical decision support.

Experiences and attitudes towards agitated behaviours in TBI ICU patients (EXSTATIC): understanding various management practices through qualitative interviews with nurses.

Introduction & Objectives: Agitation is a common complication after an acute TBI in ICU patients. Professionals have a range of strategies to address agitation. Yet the absence of evidence-based guidelines and how these strategies are implemented complicates the management and safety may often be compromised for both ICU professionals and patients.

Development and validation of a high-performance liquid chromatography method with fluorescence detection for the quantification of the resistance protein P-gp in cancer cells.

A method using high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) was developed and validated to quantify the innovative tool LightSpot®-FL-1, a selective permeability-glycoprotein (P-gp)-targeted fluorescent conjugate used to measure P-gp expression in cell samples. Quantifying P-gp is a major challenge in oncology as its overexpression in many cancer cells results in Multidrug Resistance (MDR) associated with chemotherapy failure. To develop the method reported herein, both sample preparation and analysis parameters were investigated.

Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study.

Objectives: Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneous manifestations. First-line treatment is based on colchicine, hydroxychloroquine, dapsone or low-dose glucocorticoids. In refractory forms, the use of biologics has been anecdotally described as potentially effective.