Publications by authors named "M E Quintas"
Introduction: A need for better treatment options for moderate to severe ulcerative colitis (UC) persists because of the efficacy and safety limitations of current therapies. Neutrophil epithelial transmigration is associated with the characteristic colonic mucosal inflammation in and very likely involved with the pathogenesis and clinical symptoms of UC. ADS051 is a small-molecule inhibiting neutrophil migration and activation, which are potentially important therapeutic targets in UC.
View Article and Find Full Text PDFThe creation of new firms is an important incentive for the economic growth of a country, since it generates employment, it encourages the competition, and promotes innovation. In this work, we investigate the survival of Spanish firms which were created since 2001 and closed down between 2004 and 2012. The information was gathered from Technological Innovation Panel (PITEC), a survey with a focus the technological innovation in Spanish firms.
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- Most SNPs linked to complex diseases are found in non-coding genome regions, and their role in gene expression and disease is not well understood.
- A new workflow was developed to prioritize the importance of non-coding SNPs in neurological disorder genes, using migraines as a case study.
- The study identified specific non-coding SNPs with high regulatory potential that could impact gene expression related to migraine susceptibility.
Background: Migraine is a multifactorial disorder that is more frequent (two to four times) in women than in men. In recent years, our research group has focused on the role of neurotransmitter release and its regulation. Neurexin (NRXN2) is one of the components of the synaptic vesicle machinery, responsible for connecting intracellular fusion proteins and synaptic vesicles.
View Article and Find Full Text PDFObjective: A number of observations, including among our study population, have implicated variants in the syntaxin-1A, a component of the synaptic vesicles, in migraine susceptibility. Therefore, we hypothesize that variants in other components of the vesicle machinery are involved in migraine.
Background: Migraine is a common and complex neurologic disorder that affects approximately 15-18% of the general population.