Publications by authors named "M E Porteous"
This multi-arm, parallel group, single-blinded randomised controlled trial aimed to assess three commercially available mouthwashes effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript has been written in accordance with the CONSORT statement. Eligible participants were SARS-CoV-2 positive with a positive test in the last 72 h.
View Article and Find Full Text PDFBackground: Primary graft dysfunction (PGD) contributes substantially to both short- and long-term mortality after lung transplantation, but the mechanisms that lead to PGD are not well understood. Exposure to ambient air pollutants is associated with adverse events during waitlisting for lung transplantation and chronic lung allograft dysfunction, but its association with PGD has not been studied. We hypothesized that long-term exposure of the lung donor and recipient to high levels of ambient air pollutants would increase the risk of PGD in lung transplant recipients.
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- - The study analyzed data from the CARE-MND database and the Scottish Regenerative Neurology Tissue Bank to explore the genetic factors and traits associated with motor neuron disease (MND) in a cohort of affected individuals.
- - Among 339 participants, 13% had identifiable genetic variants linked to MND, with 8.8% having a known C9orf72 repeat expansion, which was linked to poorer cognitive scores.
- - The findings highlight the importance of early genetic testing for cognitive impairment in MND patients, particularly in Scotland, where certain genetic variants are more prevalent, potentially influencing future treatment strategies.
Article Synopsis
- The study aimed to evaluate visual acuity and structural biomarkers in individuals with neovascular age-related macular degeneration (nAMD) before and 24 months after standard treatment, focusing on both the first and newly affected second eye.
- Conducted as a prospective observational study across 22 centers, it included older adults with new onset nAMD in their first eye, utilizing various assessments like OCT and quality of life measurements.
- Results showed that the second eye, diagnosed early, had significantly better visual acuity and lower rates of certain structural issues compared to the first eye, although it experienced a higher prevalence of subretinal fluid after 24.9 months. *
Introduction: Paget's disease of bone (PDB) frequently presents at an advanced stage with irreversible skeletal damage. Clinical outcomes might be improved by earlier diagnosis and prophylactic treatment.
Methods: We randomised 222 individuals at increased risk of PDB because of pathogenic variants to receive 5 mg zoledronic acid (ZA) or placebo.