In search of problems.

With early training in physics, my career was marked by continuous learning and searching for interesting problems in biology. Here, I recount some key events that influenced my choices of research topics. The diversity of topics could be attributed to my own lack of a particular focus and the interests of students and postdocs who happened to join my laboratory.

Assessing the impact of Arctic shipping routes on the global container shipping network's connectivity.

Amidst the intensifying impact of climate change, the extension of navigable periods along Arctic Shipping Routes (ASRs) has garnered attention as a maritime route for container vessels. The urgency to comprehend the reverberations of ASRs on the global container shipping network (GCSN) led to the development of the Latitudinal Centrality Index (LCI), which integrates latitude and centrality in maritime analysis. This index evaluates ASRs' influence across 968 port nodes within the GCSN.

Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming.

We investigate how matrix stiffness regulates chromatin reorganization and cell reprogramming and find that matrix stiffness acts as a biphasic regulator of epigenetic state and fibroblast-to-neuron conversion efficiency, maximized at an intermediate stiffness of 20 kPa. ATAC sequencing analysis shows the same trend of chromatin accessibility to neuronal genes at these stiffness levels. Concurrently, we observe peak levels of histone acetylation and histone acetyltransferase (HAT) activity in the nucleus on 20 kPa matrices, and inhibiting HAT activity abolishes matrix stiffness effects.