Publications by authors named "M E Polhemus"
Article Synopsis
- The study aimed to assess the safety, immune response, and effectiveness of the malaria vaccine RTS,S/AS02 when combined with another protein (FMP1) in healthy adults.
- Sixty participants were divided into four groups to receive different vaccine combinations, and results indicated that co-administering RTS,S and FMP1 at the same site decreased RTS,S antibody levels but maintained similar levels of safety and cellular immune response.
- Immunized groups with RTS,S showed about 30% efficacy in preventing malaria after exposure, while the FMP1 alone group did not demonstrate any protective effect.
Dengue, chikungunya, and Zika are arboviruses that cause 390 million infections annually. Risk factors for hospitalization are poorly understood. Communities affected by these diseases have an escalating prevalence of allergies and obesity, which are linked to immune dysfunction.
View Article and Find Full Text PDFThe management of mosquito-borne diseases is a challenge in southern coastal Ecuador, where dengue is hyper-endemic and co-circulates with other arboviral diseases. Prior work in the region has explored social-ecological factors, dengue case data, and entomological indices. In this study, we bring together entomological and epidemiological data to describe links between social-ecological factors associated with risk of dengue transmission at the household level in Machala, Ecuador.
View Article and Find Full Text PDFBackground: Dengue human infection models (DHIM) have been used as a safe means to test the viability of prophylaxis and therapeutics.
Methods: A phase 1 study of 12 healthy adult volunteers using a challenge virus, DENV-1-LVHC strain 45AZ5, was performed. A dose escalating design was used to determine the safety and performance profile of the challenge virus.
Background: The World Health Organization recommends intradermal (ID) administration of rabies vaccine for preexposure prophylaxis.
Methods: In a randomized trial in adults assigned to 1 of 6 treatment groups (ID vs intramuscular [IM], 2 vs 3 doses, and controls), rabies neutralizing antibody titers were measured to 1 year postvaccination.
Results: ID vaccination produced acceptable antibody levels in all subjects (2- and 3-dose groups).