Publications by authors named "M E Pinkerton"
Despite the recognition that heterogeneous nuclear ribonucleoproteins (hnRNPs) modulate TDP-43 and can limit aberrant splicing events to compensate for TDP-43 loss, their role in TDP-43 proteinopathies remains poorly understood and studies in patient tissue are lacking. This study assesses seven heterogeneous nuclear ribonucleoproteins from the A/B, C, D and H subfamilies in two cortical regions implicated in early TDP-43 dysfunction versus late TDP-43 dysfunction in sporadic amyotrophic lateral sclerosis and/or frontotemporal lobar degeneration. Our results reveal significant nuclear loss of hnRNPD, hnRNPC and hnRNPA1 in the frontal cortex of frontotemporal lobar degeneration compared to amyotrophic lateral sclerosis but not in the motor cortical neurons or Betz cells of amyotrophic lateral sclerosis cases.
View Article and Find Full Text PDFAntarctic toothfish (Dissostichus mawsoni) in the Ross Sea region are believed to spawn predominantly in the northern parts of the Ross Gyre during the austral winter with fluctuations in their recruitment observed. This Lagrangian modelling study attempts to explain these fluctuations and shows how sea-ice drift impacts the buoyant eggs and the overall recruitment of juveniles reaching the Amundsen shelf break. Interannual variations in the Amundsen Sea Low, linked to tropical sea surface temperatures, cause modulations in the sea-ice drift and subsequent recruitment.
View Article and Find Full Text PDFArticle Synopsis
- Increased surveillance and pathogen characterization are crucial due to rising infectious disease outbreaks in humans and animals, and genomics is a key tool for this purpose.
- A metagenomic sequencing study in Wisconsin identified 20 bacterial species in the lung tissue of white-tailed deer affected by pneumonia-related fatalities, with one species showing increased detection but not statistically significant differences between affected and healthy deer.
- The study found no significant DNA evidence of viruses or fungi in the pneumonia cases, emphasizing the role of bacterial infections and providing a foundational list of microbes for future research on this issue.
Article Synopsis
- - Researchers discovered a deepwater skate egg case nursery at around 460 meters depth off Cape Adare in the Southern Ocean, which is significant for skate populations.
- - This is the first confirmed observation of a skate nursery in the Ross Sea and only the second in the entire Southern Ocean.
- - The egg cases are likely from the genus Bathyraja, particularly Bathyraja sp. (cf. eatonii), and the nursery is located within a protected area where commercial fishing is banned.
Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis.
Acta Neuropathol Commun
November 2023
Background: Despite the presence of significant cortical pTDP-43 inclusions of heterogeneous morphologies in patients diagnosed with amyotrophic lateral sclerosis (ALS), pathological subclassification is routinely performed in the minority of patients with concomitant frontotemporal dementia (FTD).
Objective: In order to improve current understanding of the presence and relevance of pathological pTDP-43 subtypes in ALS, the present study examined the pattern of cortical pTDP-43 aggregates in 61 ALS cases without FTD.
Results: Based on the presence, morphology and composition of pTDP-43 pathology, three distinct ALS-TDP subtypes were delineated: (1) A predominant pattern of pTDP-43 granulofilamentous neuronal inclusions (GFNIs) and grains that were immuno-negative for p62 was identified in 18% of cases designated ALS-TDP type E; (2) neuronal cytoplasmic inclusions (NCIs) that were immuno-positive for both pTDP-43 and p62 were observed in 67% of cases assigned ALS-TDP type B; and (3) scarce cortical pTDP-43 and p62 aggregates were identified in 15% of cases coined ALS-TDP type SC (scarce cortical).