Publications by authors named "M E Perazzi"
Article Synopsis
- CLL patients are particularly vulnerable to COVID-19 due to weakened immune systems from their condition and treatments, highlighting the critical need for vaccination.
- The study assessed T cell responses to COVID-19 vaccines using an AIM assay, revealing that 28.60% of CLL patients did not respond to vaccination, and 61.90% exhibited impaired CD8+ T cell responses.
- The AIM test could serve as an effective tool for identifying non-responders and evaluating the immune protection of CLL patients following vaccination.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily affects the motor neurons in the brain and spinal cord. While the exact cause of ALS is not fully understood, a combination of genetic and environmental factors is believed to contribute to its development. Growth arrest-specific 6 (Gas6), a vitamin K-dependent protein, has been recognized to enhance oligodendrocytes and neurons' survival and is associated with different kinds of (neuro)inflammatory conditions.
View Article and Find Full Text PDFBackground: Modern imaging techniques with magnetic resonance imaging (MRI) or positron emission tomography/computed tomography (PET/CT) have recently been developed to assess radiation-induced damage to salivary structures. The primary aim of this review was to summarize evidence on the imaging modalities used for the assessment and prediction of xerostomia after head and neck radiotherapy (RT).
Methods: A systematic review of the literature was performed using successively the MeSH terms "PET," "MRI," "scintigraphy," "xerostomia," and "radiotherapy.
Article Synopsis
- The study investigates the effectiveness of compression ultrasound (CUS) for diagnosing venous thromboembolism (VTE), particularly pulmonary embolism (PE) and deep vein thrombosis (DVT), in hospitalized patients presenting with respiratory issues.
- Out of 263 patients, CUS identified DVT in 31 individuals, and a follow-up CT scan confirmed PE in 9 of them, revealing flaws in the Wells score's ability to accurately predict VTE risk.
- The research suggests that routinely using CUS could enhance diagnostic accuracy for VTE in patients with dyspnea or respiratory failure admitted to internal medicine.
Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular injury, extracellular matrix deposition, autoimmunity, inflammation, and fibrosis. The clinical complexity and high heterogeneity of the disease make the discovery of potential therapeutic targets difficult. However, the recent progress in the comprehension of its pathogenesis is encouraging.
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