Publications by authors named "M E P van den Elzen"
Background: The pathogenesis of chronic spontaneous urticaria (CSU), including the mechanism of action of omalizumab, remain unclear. We hypothesized complement system involvement given the often fast clinical response induced by treatment, including omalizumab. Therefore, we assessed the role of various complement factors surrounding omalizumab treatment.
View Article and Find Full Text PDFBackground: The pathogenesis of chronic spontaneous urticaria (CSU) and the mechanism of action of omalizumab in CSU remain unclear.
Objective: In this study, we assessed the responsiveness and FcεRI expression of various subsets of leucocytes in patients with CSU treated with omalizumab.
Methods: In this prospective cohort study, 30 patients were treated with 6 administrations of 300 mg omalizumab every 4 weeks, followed by a follow-up period of 12 weeks.
Background: Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU.
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- Treatment with second-generation antihistamines is effective for chronic spontaneous urticaria (CSU) patients, but many require higher doses for better results, with 78% experiencing up-dosing and 23% responding favorably.
- A majority of patients (80%) with wheals or wheals and angioedema needed higher doses, and those who didn't respond to fourfold doses had some success with even higher dosages.
- Side effects were reported by 20% of patients with a minimal increase for those on extremely high doses, suggesting that higher dosages may be a viable treatment option to reduce reliance on more complex therapies.
Assessing the INDCs' land use, land use change, and forest emission projections.
Carbon Balance Manag
December 2016
Background: In preparation for the 2015 international climate negotiations in Paris, Parties submitted Intended Nationally Determined Contributions (INDCs) to the United Nations Framework Convention on Climate Change (UNFCCC) expressing each countries' respective post-2020 climate actions. In this paper we assess individual Parties' expected reduction of emissions/removals from land use, land use change, and forest (LULUCF) sector for reaching their INDC target, and the aggregate global effect on the INDCs on the future development of emission and removals from the LULUCF sector. This has been done through analysis Parties' official information concerning the role of LULUCF mitigation efforts for reaching INDC targets as presented in National Communications, Biennial Update Reports, and Additional file 1.
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