Comparative investigation of hepatic blood flow in patients, suffering hepatic cirrhosis in compensated and decompensated stage, was performed. Characteristic peculiarities of arterial and portal hepatic blood flow were revealed, what has important diagnostic significance and must be taken in account while choosing methods of surgical and miniinvasive treatment of patients.
View Article and Find Full Text PDFThe causes of occurrence and pathogenesis of the most frequent complications, occurring after operations, made on hepatopancreatoduodenal zone organs, using minimally invasive and open accesses, were analyzed. Efficacy of domestic preparation Famozol for prophylaxis of an acute postoperative pancreatitis and the gut stress ulcers was studied.
View Article and Find Full Text PDFWide introduction of laparoscopic cholecystectomy (LCHE) caused during last 20 years a significant enhancement of rate of the biliary ducts injuries (BDI). Taking into account the experience gained in performing of more than 40,000 operations of LCHE in a leading clinics, including such in a technically complex situations, as well as experience of more than 500 operations performance for BDI, clinical recommendations, based on principles of a substantiality medicine were elaborated. More than 100 sources of foreign and domestic literature were analyzed, summarizing the results of more than 150,000 operations of LCHE, special attention was drawn to the sources I (meta-analysis and prospective randomized investigations) and II (systematic reviews, thoroughly planned prospective comparative investigations) levels of substantiality.
View Article and Find Full Text PDFComplex application of lisinopril (inhibitor of angiotensin-converting enzyme) and lovastatin (inhibitor of HMG-CoA reductase) inhibits pancreatic fibrosis in the rats, having alcoholic chronic pancreatitis after distal pancreatic resection (DPR). Lisinopril and lovastatin were injected to the rats after DPR in dose 10 mg/kg during 3 weeks. Immunohistochemical markets, such as alpha-smooth-muscle actin (alpha-SMA), desmin, glial fibrillary acidic protein (GFAP), vimentin, and expression of matrix metalloproteinase-1 (MMP-1) as well as inhibitor of matrix metalloproteinase-2 (TIMP-2) were detected for estimation of therapeutic impact on activity and quantity of stellate pancreatic cells.
View Article and Find Full Text PDFIn 2002-2012 yrs in The Department of Laparoscopic Surgery and Choledocholithiasis laparoscopic adrenalectomy (LA) for various adrenal gland diseases was done in 94 patients. The operation time while doing right-sided and left-sided LA have had constituted, accordingly, at average (73.6 +/- 12.
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