Publications by authors named "M E Morra"
Introduction: Vasectomy is a form of permanent contraception in men that is safe and effective. Complications are relatively uncommon, although patients may experience postoperative pain. Current literature quotes a broad range in the incidence of chronic orchialgia following no-scalpel vasectomy from 0.
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- A 52-year-old man presented to the emergency department with chest pain and shortness of breath, leading to a CT scan that revealed a right pulmonary embolism and inferior vena cava thrombus.
- Following the diagnosis, the patient started emergency anticoagulant therapy and was later diagnosed with nephrotic syndrome (NS).
- A renal biopsy confirmed minimal change disease, which resolved on its own, underscoring the serious nature of NS as it can first manifest through significant venous blood clots.
To endow an implant surface with enhanced properties to ensure an appropriate seal with the host tissue for inflammation/infection resistance, next-generation bone implant collagen-polyphenol nanolayers were built on conventional titanium surfaces through a multilayer approach. X-ray Photoelectron Spectroscopy (XPS) analysis was performed to investigate the chemical arrangement of molecules within the surface layer and to provide an estimate of their thickness. A short-term (2 and 4 weeks) in vivo test of bone implants in a healthy rabbit model was performed to check possible side effects of the soft surface layer on early phases of osteointegration, leading to secondary stability.
View Article and Find Full Text PDFObjective: To evaluate the effectiveness of Eutectic Mixture of Local Anesthetic (EMLA), a topical anesthetic cream, in office-based invasive andrological procedures such as hydrocelectomy, spermatocelectomy, and others, aimed at minimizing pain perception and enhancing the overall patient experience.
Methods: A double-blinded randomized controlled trial was conducted for patients undergoing scrotal andrology surgeries under LA. Power calculation was performed with an estimated sample size of 72.
Article Synopsis
- Lipid nanoparticle (LNP)-encapsulated mRNA can produce various therapeutic proteins in vivo, facilitating the creation of personalized cancer vaccines and enhancing drug delivery methods.
- The study demonstrated that mRNA/LNP formulations of specific proteins substantially increased their production and presence in tumors compared to traditional recombinant proteins, with up to 140-fold improvement in exposure over 96 hours.
- Additionally, these formulations stimulated a stronger immune response, prolonged survival in cancer models, and showed improved efficacy when combined with existing treatments, suggesting potential for better patient outcomes.