Treatment options for Achilles tendinopathy: a scoping review of preclinical studies.

Background: Achilles tendinopathy (AT) management can be difficult, given the paucity of effective treatment options and the degenerative nature of the condition. Innovative therapies for Achilles tendinopathy are therefore direly needed. New therapeutic developments predominantly begin with preclinical animal and in vitro studies to understand the effects at the molecular level and to evaluate toxicity.

Understanding Daily Care Experience Preferences Across the Lifespan of Older Adults: Application of Natural Language Processing.

Introduction: Older adults are a heterogeneous group, and their care experience preferences are likely to be diverse and individualized. Thus, the aim of this study was to identify categories of older adults' care experience preferences and to examine similarities and differences across different age groups.

Methods: The initial categories of older adults' care experience preferences were identified through a qualitative review of narrative text (n = 3134) in the ADVault data set.

Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.

Hematopoietic progenitor kinase 1 (HPK1/MAP4K1) represents a high interest target for the treatment of cancer through an immune-mediated mechanism. Herein we present highlights of the drug discovery campaign within the lactam/azalactam series of inhibitors that yielded a small molecule (, PF-07265028), which was advanced to a phase 1 clinical trial (NCT05233436). Key components of the discovery effort included optimization of potency through mitigation of ligand strain as guided by the use of cocrystal structures, mitigation of ADME liabilities (plasma instability and fraction metabolism by CYP2D6), and optimization of kinase selectivity, particularly over immune-modulating kinases with high homology to HPK1.

The offense characteristics of maternal filicides in eSwatini: adding to Resnick's classification model.

Introduction: Maternal filicide, the murder of a child by a mother, is a complex phenomenon. Relatively little is known of filicide on the African continent, especially in eSwatini. This study highlights the complex dynamics at play when these crimes are committed.

Mental health symptoms among Dutch elite athletes and their coaches: a cross-sectional study.

Objective: To establish the prevalence of mental health symptoms (MHSs ) among Dutch elite athletes and their coaches, to examine the association between potential contributing factors and MHS among Dutch elite athletes and their coaches and to explore the view and needs of Dutch elite athletes and their coaches regarding mental health resources and support.

Methods: A cross-sectional study was conducted by distributing an electronic questionnaire based on validated screening questionnaires for the assessment of MHS.

Results: In total, 156 athletes (55 % female) and 95 coaches (79 % male) across various sports participated in this study.