Biomarkers.

Background: To date, all computerised perivascular spaces (PVS) quantification methods require case-wise, imaging modality, or study-specific parameter adjustments, and suffer from generalisability problems in clinical settings, and misdetection of other cerebral small vessel disease (CSVD) markers. We propose a deep learning-based PVS detection method to overcome these issues. We compare our proposal on magnetic resonance imaging data of CSVD participants against the performance of the Frangi filter.

Biomarkers.

Background: The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is one of the biggest health concerns of the century. Long COVID is one of the major sequelae from the infection and include persistent neurological manifestations. Brain images study suggest that Long COVID patients present distinct brain metabolic alterations.

Biomarkers.

Background: Current evidence indicates that COVID-19 infection can lead to neurological complications that persist beyond 12 weeks of infection (long-COVID), often associated with cognitive decline. However, the underlying mechanisms remain unclear. Our aim is to study the brain metabolism of patients with long-COVID and its association with cognitive performance.

Continuous endoscopic manual suturing for colorectal anastomotic fistula closure.

A 54-year-old male underwent a low anterior resection in 2015 for rectal adenocarcinoma. He presented to the emergency department with a two-week history of fever, perianal pain, an erythematous, warm, and actively draining mass. Physical examination revealed a perianal abscess in the left posterior gluteal region, with a palpable internal fistulous orifice 3 cm from the anal margin.

Biomarkers.

Background: The persisting cognitive symptoms observed in individuals after a Covid-19 infection (long-Covid) remain an enigmatic aspect of the disease. Clinical descriptions in the literature are dissimilar, suggesting more than one clinical phenotype. Our study aims to explore cognitive performance and brain network of long-Covid patients, to determine the neural correlates of cognitive impairment.