The presence of multiple hydroxyl groups at positions C2, C3 and C6 on the cyclodextrin (CD) ring structure allows for extensive functionalisation, enabling the development of biomaterials with significant potential for therapeutic siRNA delivery. To identify structural modifications that enhance activity, a range of cationic amphiphilic CDs, including both β- and γ-CDs, were synthesised, compared and evaluated. Each CDs incorporated a C lipid chain on the primary face of the CD.
View Article and Find Full Text PDFPaediatr Perinat Epidemiol
December 2024
Background: The Giacomini vein (GV) can transfer reflux from perineal veins, tributary veins, and perforators of the thigh to the small saphenous vein (SSV). Vascular ultrasound with Doppler (VUD) is the preferred method for detecting reflux in specific veins such as the GV.
Objective: To identify GV depth and diameter, reflux in the GV, and presence of reflux in the SSV caused by the GV.