Investigating how reproductive traits in rice respond to abiotic stress.

Oryza sativa is one of the most important crops and a food source for billions of people. Anthropic global warming, soil erosion, and unstable environmental conditions affect both its vegetative and reproductive growth, and consequently the final yield of its cultivation. The reproductive phase starts with the transition of apical meristem from vegetative to reproductive, which develops into a panicle, proceeds through the differentiation of the floret, and, after fertilization, the filling of the grain.

Cost-effectiveness of a machine learning risk prediction model (LungFlag) in the selection of high-risk individuals for non-small cell lung cancer screening in Spain.

Objective: The LungFlag risk prediction model uses individualized clinical variables to identify individuals at high-risk of non-small cell lung cancer (NSCLC) for screening with low-dose computed tomography (LDCT). This study evaluates the cost-effectiveness of LungFlag implementation in the Spanish setting for the identification of individuals at high-risk of NSCLC.

Methods: A model combining a decision-tree with a Markov model was adapted to the Spanish setting to calculate health outcomes and costs over a lifetime horizon, comparing two hypothetical scenarios: screening with LungFlag versus non-screening, and screening with LungFlag versus screening the entire population meeting 2013 US Preventive Services Task Force (USPSTF) criteria.

Long-Term Effectiveness and Safety of Ustekinumab in Crohn's Disease: Results from a Large Real-Life Cohort Study.

Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Only limited real-life data on the long-term outcomes of CD patients treated with UST are available. This study assessed UST's long-term effectiveness and safety in a large population-based cohort of moderate to severe CD patients.

Auxin response factor 10 insensitive to miR160regulation induces apospory-like phenotypes in .

The megaspore mother cell (MMC) arises from somatic cells in the ovule primordium and enters meiosis to generate four megaspores. Only the most chalazal (functional megaspore, FM) survives, undergoing a series of mitoses to form the female gametophyte. We show that this commitment to the sexual germline requires spatial regulation of ().