Publications by authors named "M E Martinez-Lozano"
Article Synopsis
- Researchers used broadband diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) to assess deep tissue blood characteristics in a mouse model of clear cell renal cancer being treated with sunitinib.
- The study involved 22 treated mice and 13 untreated controls, revealing significant reductions in total hemoglobin concentration, oxygen saturation, and blood flow index during treatment.
- Findings indicated that early changes in blood flow and hemoglobin levels were linked to tumor characteristics, suggesting DRS/DCS can help predict how tumors might respond to antiangiogenic therapies.
Aims/hypothesis: Many studies have examined the relationship between plasma metabolites and type 2 diabetes progression, but few have explored saliva and multi-fluid metabolites.
Methods: We used LC/MS to measure plasma (n=1051) and saliva (n=635) metabolites among Puerto Rican adults from the San Juan Overweight Adults Longitudinal Study. We used elastic net regression to identify plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting baseline HOMA-IR in a training set (n=509) and validated these scores in a testing set (n=340).
Objective: To evaluate the impact of Hurricanes Irma and Maria on 3 major chronic diseases in Puerto Rico.
Methods: San Juan Overweight Adults Longitudinal study participants were re-evaluated after Hurricanes Irma and Maria (May 2019-July 2020) for the Preparedness to Reduce Exposures and Diseases Post-hurricanes and Augment Resilience study. This study compared the prevalence and incidence of asthma, depression, and hypertension within the same 364 individuals over time.
Objective: To evaluate the impact of Hurricanes Irma/Maria on diabetes incidence in Puerto Rico. Mortality increased substantially after the hurricanes, but morbidity was not assessed.
Methods: We recruited 364 participants from the San Juan Overweight Adults Longitudinal Study (SOALS) aged 40-65 years who completed a three-year follow-up and were free of diabetes.