High dioptric power micro-lenses fabricated by two-photon polymerization.

Specimen-induced aberrations limit the penetration depth of standard optical imaging techniques in vivo, mainly due to the propagation of high NA beams in a non-homogenous medium. Overcoming these limitations requires complex optical imaging systems and techniques. Implantable high NA micro-optics can be a solution to tissue induced spherical aberrations, but in order to be implanted, they need to have reduced complexity, offering a lower surface to the host immune reaction.

New insights into persistent corneal subepithelial infiltrates following epidemic keratoconjunctivitis: The first case report with ultrastructural and immunohistochemical investigations.

Epidemic keratoconjunctivitis (EKC) is one of the most severe clinical manifestations of human adenovirus ocular surface infection, which may lead to the formation of subepithelial infiltrates (SEIs) in the anterior corneal stroma in 20-50 % of cases. SEIs may be asymptomatic or give rise to corneal aberrations and visual impairment for months or years after acute infection, despite treatments. Here, we describe the ultrastructural and immunophenotypic features of the anterior corneal stroma of a patient who underwent superficial anterior lamellar keratoplasty (SALK) surgery to remove corneal opacities related to clinically significant and steroid-unresponsive, long-lasting SEIs after adenoviral EKC.

Characterisation of periorbital mechanical allodynia in the reserpine-induced fibromyalgia model in mice: The role of the Schwann cell TRPA1/NOX1 signalling pathway.

Fibromyalgia (FM) is a complex and multifaceted condition characterized by a range of clinical symptoms, including widespread pain and a strong association with migraine headaches. Recent findings have underscored the role of oxidative stress and transient receptor potential ankyrin 1 (TRPA1) channel in migraine and FM. However, the precise mechanisms underlying the comorbidity between migraine and FM are unclear.

Continued changes to contact lens practice following adjustments made as a result of the COVID-19 pandemic.

Background: This study aimed to explore behaviour of practitioners in response to the COVID-19 pandemic, analysing the factors that influenced their decisions to resume professional practice post-lockdown and intention to adhere to COVID-19 protective measures.

Methods: A web-based cross-sectional survey targeting Italian practitioners was carried out to study the post lockdown behaviour and future intention to provide new contact lens (CL) fittings, and the use of protective measures. The survey also explored the dimensions of the Integrated Behavioural Model (IBM) and the Health Belief Model (HBM) to predict the intention to resume professional practice and to comply with protective measures respectively.

Seasonal variation in myasthenia gravis incidence.

Introduction: Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.